| First Author | Droebner K | Year | 2008 |
| Journal | J Virol | Volume | 82 |
| Issue | 22 | Pages | 11461-6 |
| PubMed ID | 18768968 | Mgi Jnum | J:142960 |
| Mgi Id | MGI:3822586 | Doi | 10.1128/JVI.01071-08 |
| Citation | Droebner K, et al. (2008) Role of hypercytokinemia in NF-kappaB p50-deficient mice after H5N1 influenza A virus infection. J Virol 82(22):11461-6 |
| abstractText | During H5N1 influenza virus infection, proinflammatory cytokines are markedly elevated in the lungs of infected hosts. The significance of this dysregulated cytokine response in H5N1-mediated pathogenesis remains to be determined. To investigate the influence of hypercytokinemia, or 'cytokine storm,' a transgenic mouse technology was used. The classical NF-kappaB pathway regulates the induction of most proinflammatory cytokines. Deletion of the p50 subunit leads to a markedly reduced expression of the NF-kappaB-regulated cytokines and chemokines. Here we show that H5N1 influenza virus infection of this transgenic mouse model resulted in a lack of hypercytokinemia but not in altered pathogenesis. |
