| First Author | Moore SF | Year | 2008 |
| Journal | Biochem Pharmacol | Volume | 76 |
| Issue | 12 | Pages | 1740-7 |
| PubMed ID | 18848528 | Mgi Jnum | J:143400 |
| Mgi Id | MGI:3826889 | Doi | 10.1016/j.bcp.2008.09.015 |
| Citation | Moore SF, et al. (2008) Species and agonist dependent zinc modulation of endogenous and recombinant ATP-gated P2X7 receptors. Biochem Pharmacol 76(12):1740-7 |
| abstractText | Zinc (Zn2+) and copper (Cu2+) are key signalling molecules in the immune system and regulate the activity of many ion channels. Both Zn2+ and Cu2+ potently inhibit rat P2X7 receptors via a binding site identified by mutagenesis. Here we show that extracellular Cu2+ also potently inhibits mouse P2X7 receptors. By contrast, the receptor expression system and agonist strongly influence the action of extracellular Zn2+ at mouse P2X7 receptors. Consistent with previous reports, Zn2+ inhibits recombinant rat P2X7 receptors. However, recombinant mouse P2X7 receptors are potentiated by Zn2+ when activated by ATP4- but inhibited when stimulated with the ATP analogue BzATP4-. Endogenous murine macrophage P2X7 receptors are not modulated by Zn2+ when stimulated by ATP4- however Zn2+ inhibits BzATP4- mediated responses. In summary, these findings provide a fundamental insight into the differential actions of Zn2+ and Cu2+ between different P2X7 receptor species. |
