| First Author | Lim K | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 3 | Pages | 512-20 |
| PubMed ID | 19070619 | Mgi Jnum | J:144230 |
| Mgi Id | MGI:3830450 | Doi | 10.1016/j.febslet.2008.12.007 |
| Citation | Lim K, et al. (2009) O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1. FEBS Lett 583(3):512-20 |
| abstractText | Sp1 is a ubiquitous transcription factor that is modified by multiple O-linked N-acetylglucosamines (O-GlcNAc). Previously, O-GlcNAcylation of a specific site of Sp1 was shown to inhibit Sp1 transcriptional activity. Yet, how O-GlcNAc on other modification sites affects Sp1 function and how O-GlcNAcylation of Sp1 affects the transcriptional regulation of a target gene remains unknown. Here we show that O-GlcNAc within the second serine/threonine-rich region of Sp1 interrupts a known interaction between Sp1 and Oct1, and inhibits the cooperative activation of the U2 snRNA gene by Sp1 and Oct1. |
