| First Author | Zhang M | Year | 2007 |
| Journal | J Immunol | Volume | 178 |
| Issue | 6 | Pages | 3483-91 |
| PubMed ID | 17339443 | Mgi Jnum | J:144288 |
| Mgi Id | MGI:3830592 | Doi | 10.4049/jimmunol.178.6.3483 |
| Citation | Zhang M, et al. (2007) Differential survival of cytotoxic T cells and memory cell precursors. J Immunol 178(6):3483-91 |
| abstractText | It is widely assumed that the development of memory CD8 T cells requires the escape of CTLs from programmed cell death. We show in this study that although serine protease inhibitor 6 (Spi6) is required to protect clonal bursts of CTLs from granzyme B-induced programmed cell death, it is not required for the development of memory cells. This conclusion is reached because memory cell precursors down-regulate both Spi6 and granzyme B, unlike CTLs, and they do not require Spi6 for survival. These findings suggest that memory CD8 T cells are derived from progenitors that are refractory to self-inflicted damage, rather than derived from fully differentiated CTLs. |
