| First Author | Watanabe R | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 377 |
| Issue | 3 | Pages | 867-72 |
| PubMed ID | 18951876 | Mgi Jnum | J:144879 |
| Mgi Id | MGI:3832130 | Doi | 10.1016/j.bbrc.2008.10.074 |
| Citation | Watanabe R, et al. (2008) Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells. Biochem Biophys Res Commun 377(3):867-72 |
| abstractText | Activins regulate pancreatic development, differentiation and insulin secretion. Activin receptor-like kinase 7 (ALK7) has been identified as a receptor for Nodal and Activin AB and B, and is expressed in pancreatic islets and beta-cell lines. In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway. A conserved Smad binding element was related to the promoter activation. Phosphorylated Smad2/Smad3 and PDX-1 were bound to insulin gene with Nodal and Activin AB, and the phosphorylated Smad2/Smad3 interacted with PDX-1. These results indicate that one of the direct target genes of Nodal and Activin AB signals is the insulin gene in pancreatic beta-cells and that PDX-1 is directly involved in the ALK7-Smad pathway. |
