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Publication : Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development.

First Author  Li T Year  2009
Journal  Genomics Volume  93
Issue  3 Pages  235-42
PubMed ID  19015022 Mgi Jnum  J:146970
Mgi Id  MGI:3839041 Doi  10.1016/j.ygeno.2008.10.006
Citation  Li T, et al. (2009) Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development. Genomics 93(3):235-42
abstractText  The liver performs a number of essential functions for life. The development of such a complex organ relies on finely regulated gene expression profiles which change over time in the development and determine the phenotype and function of the liver. We used high-density oligonucleotide microarrays to study the gene expression and transcription regulation at 14 time points across the C57/B6 mouse liver development, which include E11.5 (embryonic day 11.5), E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5, Day0 (the day of birth), Day3, Day7, Day14, Day21, and normal adult liver. With these data, we made a comprehensive analysis on gene expression patterns, functional preferences and transcriptional regulations during the liver development. A group of uncharacterized genes which might be involved in the fetal hematopoiesis were detected.
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