| First Author | Yoon SH | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 7 | Pages | 1164-70 |
| PubMed ID | 19285079 | Mgi Jnum | J:147997 |
| Mgi Id | MGI:3843133 | Doi | 10.1016/j.febslet.2009.03.005 |
| Citation | Yoon SH, et al. (2009) Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling. FEBS Lett 583(7):1164-70 |
| abstractText | Osteoclasts differentiate from macrophage-lineage cells to become specialized for bone resorption function. By a proteomics approach, we found that Lyn was down-regulated by the osteoclast differentiation factor, receptor activator of NF-kappaB ligand (RANKL). The forced reduction of Lyn caused a striking increase in the RANKL-induced PLCgamma1, Ca(2+), and NFATc1 responses during differentiation. These data suggest that Lyn plays a negative role in osteoclastogenesis by interfering with the PLCgamma1-mediated Ca(2+) signaling that leads to NFATc1 activation. Consistent with the in vitro results, in vivo injection of Lyn specific siRNA into mice calvariae provoked a fulminant bone resorption. Our study provides the first evidence of the involvement of Lyn in the negative regulation of osteoclastogenesis by RANKL. |
