| First Author | Kelly KJ | Year | 2009 |
| Journal | Am J Physiol Renal Physiol | Volume | 296 |
| Issue | 6 | Pages | F1355-63 |
| PubMed ID | 19321596 | Mgi Jnum | J:148705 |
| Mgi Id | MGI:3846259 | Doi | 10.1152/ajprenal.90622.2008 |
| Citation | Kelly KJ, et al. (2009) Acute-phase response protein serum amyloid A stimulates renal tubule formation: studies in vitro and in vivo. Am J Physiol Renal Physiol 296(6):F1355-63 |
| abstractText | Serum amyloid A protein (SAA) surges 1,000-fold in the blood of acute-phase animals, and yet its function during these acute events remains unknown. We report herein that SAA stimulates a developmental program in cultured NRK-52E cells that culminates in differentiated and functional tubules that feature a proximal tubule phenotype. We also found strong SAA expression in states of tubule formation (in utero stage) and regeneration (recovery from ischemia-reperfusion injury). These data lend support to a novel view of a more localized renal acute-phase reaction, where renal SAA may act as a paracrine or autocrine molecule that promotes tubule formation during development and repair. |
