| First Author | Yao K | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 13 | Pages | 2208-12 |
| PubMed ID | 19527717 | Mgi Jnum | J:150843 |
| Mgi Id | MGI:3851887 | Doi | 10.1016/j.febslet.2009.06.017 |
| Citation | Yao K, et al. (2009) A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett 583(13):2208-12 |
| abstractText | Indiscriminately suppressing total c-Jun N-terminal kinase (JNK) activity is not an appropriate strategy because each JNK appears to have a distinct function in cancer, asthma, diabetes, or Parkinson's disease. Herein, we report that 7-(6-N-phenylaminohexyl)amino-2H-anthra[1,9-cd]pyrazol-6-one (AV-7) inhibited JNK1 activity, but not JNK2 or JNK3. We found that ultraviolet B (UVB) induced c-Jun phosphorylation and sub-G1 accumulation in JNK2(-/-) murine embryonic fibroblasts, which contain an abundance of JNK1, but not JNK2. These results demonstrate that AV-7 is an isoform selective small-molecule inhibitor of JNK1 activity, which might be developed as a therapeutic against diabetes. |
