| First Author | Yang J | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 18 | Pages | 3009-15 |
| PubMed ID | 19683528 | Mgi Jnum | J:152796 |
| Mgi Id | MGI:4359986 | Doi | 10.1016/j.febslet.2009.08.008 |
| Citation | Yang J, et al. (2009) PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells. FEBS Lett 583(18):3009-15 |
| abstractText | PANDER is a cytokine co-secreted with insulin from islet beta-cells. To date, the physiological function of PANDER remains largely unknown. Here we show that PANDER binds to the liver membrane by (125)I-PANDER saturation and competitive binding assays. In HepG2 cells, pre-treatment with PANDER ranging from 4 pM to 4 nM for 8h resulted in a maximal inhibition of insulin-stimulated activation of insulin receptor and insulin receptor substrate 1 by 52% and 63%, respectively. Moreover, PANDER treatment also reduced insulin-stimulated PI3K and pAkt levels by 55% and 48%, respectively. In summary, we have identified the liver as a novel target for PANDER, and PANDER may be involved in the progression of diabetes by regulating hepatic insulin signaling pathways. |
