| First Author | Mikura A | Year | 2009 |
| Journal | Congenit Anom (Kyoto) | Volume | 49 |
| Issue | 2 | Pages | 77-84 |
| PubMed ID | 19489959 | Mgi Jnum | J:153103 |
| Mgi Id | MGI:4360861 | Doi | 10.1111/j.1741-4520.2009.00227.x |
| Citation | Mikura A, et al. (2009) Association of tenascin-W expression with mineralization in mouse calvarial development. Congenit Anom (Kyoto) 49(2):77-84 |
| abstractText | Tenascin-W is a tenascin family member that forms part of a complex extracellular matrix, and previous studies have suggested its association with osteogenesis. In the present study we investigated the roles of tenascin-W in osteogenesis. We found that tenascin-W is expressed in osteoblasts at the edge of the developing bone domain prior to mineralization in mouse fetuses. Expression of tenascin-W was induced during the course of mineralization of the Kusa-A1 osteoblast cell line. In the interfrontal suture of postnatal mice, the anterior portion remains patent and the posterior portion closes by 4 weeks of age. Tenascin-W expression was downregulated at 1 week of age in the posterior frontal suture, whereas in the anterior suture, expression was maintained until the mice reached 4 weeks of age. Fibroblast growth factor 2 (FGF2)-bead application to the mouse fetal skull by ex-utero surgery accelerated osteoblast differentiation, but inhibited mineralization with a downregulation of tenascin-W expression. These results suggest that tenascin-W is involved in osteoblast maturation (i.e. mineralization). |
