| First Author | Jiang Z | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 21 | Pages | 3536-40 |
| PubMed ID | 19822149 | Mgi Jnum | J:153725 |
| Mgi Id | MGI:4366168 | Doi | 10.1016/j.febslet.2009.10.015 |
| Citation | Jiang Z, et al. (2009) Interplay of CCR2 signaling and local shear force determines vein graft neointimal hyperplasia in vivo. FEBS Lett 583(21):3536-40 |
| abstractText | Leukocytes play a central role in vein graft neointimal hyperplasia, which is significantly augmented under low shear conditions. The current concept is that shear force regulates leukocyte adhesion predominately through up-regulation of chemokines and growth factors within the graft wall. Using rabbit and murine vein graft models, we demonstrate that CC chemokine receptor 2/monocyte chemoattractant protein-1 mediated monocyte recruitment and a low shear environment act synergistically to augment neointimal hyperplasia development and removal of either of the conditions leads to a significant reduction in neointimal thickening. We propose a novel concept that the shear stress response element phenotypically stems from the complex interplay of the biological and physical microenvironments. |
