| First Author | Belikova NA | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 21 | Pages | 3437-42 |
| PubMed ID | 19822147 | Mgi Jnum | J:153726 |
| Mgi Id | MGI:4366169 | Doi | 10.1016/j.febslet.2009.10.013 |
| Citation | Belikova NA, et al. (2009) Radioprotection by short-term oxidative preconditioning: Role of manganese superoxide dismutase. FEBS Lett 583(21):3437-42 |
| abstractText | Manganese superoxide dismutase (MnSOD) is vital to the protection of mitochondria and cells against oxidative stress. Earlier, we demonstrated that catalytically active homo-tetramer of MnSOD can be stabilized by oxidative cross-linking. Here we report that this effect may be translated into increased radioresistance of mouse embryonic cells (MECs) by pre-exposure to oxidative stress. Pre-treatment of MECs with antimycin A, rotenone or H(2)O(2) increased their survival after irradiation. Using MnSOD siRNA, we show that MECs with decreased MnSOD levels displayed a lowered ability to preconditioning. Thus oxidative preconditioning may be used for targeted regulation of MnSOD. STRUCTURED SUMMARY: MINT-7288408: MnSOD (uniprotkb:P04179) and MnSOD (uniprotkb:P04179) physically interact (MI:0915) by zymography (MI:0512). |
