First Author | Zhao B | Year | 2009 |
Journal | Cancer Cell | Volume | 16 |
Issue | 5 | Pages | 363-4 |
PubMed ID | 19878866 | Mgi Jnum | J:153949 |
Mgi Id | MGI:4366642 | Doi | 10.1016/j.ccr.2009.10.008 |
Citation | Zhao B, et al. (2009) Mst out and HCC in. Cancer Cell 16(5):363-4 |
abstractText | Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent. |