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Publication : Mst out and HCC in.

First Author  Zhao B Year  2009
Journal  Cancer Cell Volume  16
Issue  5 Pages  363-4
PubMed ID  19878866 Mgi Jnum  J:153949
Mgi Id  MGI:4366642 Doi  10.1016/j.ccr.2009.10.008
Citation  Zhao B, et al. (2009) Mst out and HCC in. Cancer Cell 16(5):363-4
abstractText  Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent.
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