| First Author | Masumi A | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 21 | Pages | 3493-500 |
| PubMed ID | 19818776 | Mgi Jnum | J:154067 |
| Mgi Id | MGI:4367161 | Doi | 10.1016/j.febslet.2009.10.006 |
| Citation | Masumi A, et al. (2009) Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells. FEBS Lett 583(21):3493-500 |
| abstractText | Megakaryopoiesis is associated with inflammatory reactions. To investigate the role of interferon regulatory factors (IRFs) in inflammation-associated megakaryopoiesis, mouse bone marrow hematopoietic stem cells (HSCs) were analyzed. IFN-gamma treatment induced IRF-2 expression as well as the expression of CD41 and IRF-1 in HSCs. An in vitro clonogenic assay showed that IRF-2- but not IRF-1-overexpressing cells increased the number of megakaryocytic colonies. IRF-2 transfection up-regulated CD41 promoter activity in hematopoietic cell lines. The number of CD41-positive bone marrow cells increased in mice injected with IRF-2-expressing bone marrow cells. These findings suggest that IRF-2 plays an important role in megakaryopoiesis in inflammatory states. |
