| First Author | Miller LC | Year | 2009 |
| Journal | Mol Cell Neurosci | Volume | 40 |
| Issue | 4 | Pages | 485-95 |
| PubMed ID | 19340935 | Mgi Jnum | J:154145 |
| Mgi Id | MGI:4367329 | Doi | 10.1016/j.mcn.2009.01.007 |
| Citation | Miller LC, et al. (2009) Combinations of DEAD box proteins distinguish distinct types of RNA: protein complexes in neurons. Mol Cell Neurosci 40(4):485-95 |
| abstractText | Transport of mRNAs to axons and dendrites in neurons is important for growth, polarization and plasticity. Recent proteomic studies in neurons have identified a number of DEAD box proteins as components of RNA granules. Using DEAD box proteins as markers, we have defined classes of RNA:protein structures present in neurons. In particular, we demonstrate that the conjunction of DEAD box 1 and DEAD box 3 identifies a motile ribosome-containing RNA granule present in both axons and dendrites that is similar to the biochemically isolated RNA granule. Conjunction of DEAD box 1 and the novel protein CGI-99 defines a distinct complex in neurons. Attempts to define a P-body like structure with expression of DEAD box 6 and decapping enzymes suggest that this structure may be more complex in neuronal processes than in other compartments. These studies hint at a great complexity in RNA transport and storage in neuronal processes. |
