| First Author | Yamada T | Year | 2009 |
| Journal | Leuk Res | Volume | 33 |
| Issue | 3 | Pages | 483-9 |
| PubMed ID | 18692240 | Mgi Jnum | J:155188 |
| Mgi Id | MGI:4412438 | Doi | 10.1016/j.leukres.2008.07.002 |
| Citation | Yamada T, et al. (2009) Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins. Leuk Res 33(3):483-9 |
| abstractText | To examine the possibility that ETS family transcription factors, PU.1, SPI-B, ELF-1, ERG-3, ETS-1 and TEL, and homeodomain proteins, HOXA10, HOXC13, MEIS1 and PBX1B, function cooperatively, we investigated their interactions. In luciferase assays, HOXA10 and HOXC13 augmented the activity of PU.1 and SPI-B while diminishing that of ELF-1 and ERG-3. MEIS1 diminished the activity of ETS-1. No clear effects were observed for other combinations. Immunoprecipitation assays showed protein-protein interactions among the combinations exhibiting functional interactions. A mutation of HOXC13, which abolished binding to ELF-1, also abolished the diminishing effect on ELF-1. The results suggest functional interaction through physical interactions. |
