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Publication : The novel function of nesfatin-1: anti-hyperglycemia.

First Author  Su Y Year  2010
Journal  Biochem Biophys Res Commun Volume  391
Issue  1 Pages  1039-42
PubMed ID  19995555 Mgi Jnum  J:156770
Mgi Id  MGI:4421346 Doi  10.1016/j.bbrc.2009.12.014
Citation  Su Y, et al. (2010) The novel function of nesfatin-1: anti-hyperglycemia. Biochem Biophys Res Commun 391(1):1039-42
abstractText  Nesfatin-1 is recently reported as a satiety molecule to suppress food intake via the melanocortin signaling in hypothalamus when injected centrally and peripherally. Here we report that nesfatin-1 is also anti-hyperglycemic. It was found that the intravenous injection of nesfatin-1 significantly reduced blood glucose in hyperglycemic db/db mice. This anti-hyperglycemic effect of nesfatin-1 was time-, dose-, insulin-dependent and peripheral.
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