| First Author | Yang WH | Year | 2010 |
| Journal | Biochem Biophys Res Commun | Volume | 391 |
| Issue | 1 | Pages | 756-61 |
| PubMed ID | 19944066 | Mgi Jnum | J:156783 |
| Mgi Id | MGI:4421359 | Doi | 10.1016/j.bbrc.2009.11.133 |
| Citation | Yang WH, et al. (2010) O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation. Biochem Biophys Res Commun 391(1):756-61 |
| abstractText | Hyperglycemia induces activation of glutathione peroxidase 1 (GPX1), an anti-oxidant enzyme essential for cell survival during oxidative stress. However, the mechanism of GPX1 activation is unclear. Here, we report that hyperglycemia-induced protein glycosylation by O-linked N-acetylglucosamine (O-GlcNAc) is crucial for activation of GPX1 and for its binding to c-Abl and Arg kinases. GPX1 itself is modified with O-GlcNAc on its C-terminus. We also demonstrate that pharmacological injection of the O-GlcNAcase inhibitor NTZ induces GPX1 activation in the mouse liver. Our findings suggest a crucial role for GPX1 and its O-GlcNAc modification in hyperglycemia and diabetes mellitus. |
