| First Author | Ellens DJ | Year | 2009 |
| Journal | Epilepsy Res | Volume | 85 |
| Issue | 1 | Pages | 53-9 |
| PubMed ID | 19409755 | Mgi Jnum | J:157139 |
| Mgi Id | MGI:4430054 | Doi | 10.1016/j.eplepsyres.2009.01.007 |
| Citation | Ellens DJ, et al. (2009) Development of spike-wave seizures in C3H/HeJ mice. Epilepsy Res 85(1):53-9 |
| abstractText | C3H/HeJ mice have been reported to have relatively early onset of spike-wave discharges (SWD), and a defective AMPA receptor subunit Gria4 as the genetic cause. We investigated the time course of SWD development through serial EEG recordings in C3H/HeJ mice to better characterize this model. We found that at immature postnatal ages of 5-15 days, rare SWD-like events were observed at an average rate of 3 per hour, and with relatively broad spikes, irregular rhythm, slow frequency (5-6 Hz), and short duration (mean 1.75 s). This was followed by a transitional period of increasing SWD incidence, which then stabilized in mature animals at age 26-62 days, with SWD at an average rate of 45 per hour, narrower spike morphology, regular rhythm, higher frequency (7-8 Hz), and longer duration (mean 3.40s). This sequence of maturational changes in SWD development suggests that effects of early intervention could be tested in C3H/HeJ mice over the course of a few weeks, rather than a few months as in rats, greatly facilitating future research on anti-epileptogenesis. |
