| First Author | Shima H | Year | 2010 |
| Journal | Int Immunol | Volume | 22 |
| Issue | 3 | Pages | 149-56 |
| PubMed ID | 20042454 | Mgi Jnum | J:157655 |
| Mgi Id | MGI:4431317 | Doi | 10.1093/intimm/dxp121 |
| Citation | Shima H, et al. (2010) Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int Immunol 22(3):149-56 |
| abstractText | Fc receptors specifically bind to the Fc region of Igs to mediate the unique functions to each class of Igs. To identify a novel Fc receptor for IgM, we searched expressed sequence tag database for molecules containing Ig domains with homology to those of known Fc receptors for IgM, Fcalpha/muR and polymeric Ig receptor. As a result, we identified TOSO/Fas apoptotic inhibitory molecule 3 (FAIM3) as a possible Fc receptor for IgM. HeLa cells transfected with a TOSO/FAIM3-expression vector bound to IgM but not IgG and were able to internalize IgM-conjugated beads but not IgG-conjugated beads, suggesting that TOSO/FAIM3 is indeed a receptor for IgM (FcmuR). FcmuR protein was expressed predominantly on B-lineage cells; expression of the Fcmr transcripts was observed from the pre-B-cell stage and maintained thereafter during B-cell development. These results identify TOSO/FAIM3 as a receptor for IgM and suggest that FcmuR may serve as an uptake receptor for IgM-opsonized antigens by B cells. |
