| First Author | Magnusson B | Year | 2010 |
| Journal | Biochem Biophys Res Commun | Volume | 395 |
| Issue | 3 | Pages | 373-6 |
| PubMed ID | 20382119 | Mgi Jnum | J:160343 |
| Mgi Id | MGI:4454252 | Doi | 10.1016/j.bbrc.2010.04.022 |
| Citation | Magnusson B, et al. (2010) Activin B inhibits lipolysis in 3T3-L1 adipocytes. Biochem Biophys Res Commun 395(3):373-6 |
| abstractText | Activin B, consisting of two inhibin betaB (INHBB) subunits, is a hormone known to affect gonadal function, reproduction and fetal development. We have reported that INHBB and activin B receptors are highly expressed in adipocytes suggesting that activin B may have local effects in adipose tissue. In this study, we investigate the effect of activin B on lipolysis, measured as release of non-esterified fatty acids and free glycerol. Recombinant activin B decreased lipolysis in a concentration-dependent manner and increased intracellular triglyceride content in 3T3-L1 adipocytes. siRNA-mediated knock-down of INHBB expression increased lipolysis, and this effect was abolished by addition of recombinant activin B. In line with its inhibitory effect on lipolysis, activin B caused a down regulation of the expression of adipose triglyceride lipase and hormone sensitive lipase, key genes involved in lipolysis. In summary, we suggest that activin B is a novel adipokine that inhibits lipolysis in a paracrine or autocrine manner. |
