| First Author | Wang QH | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 11 | Pages | 2315-20 |
| PubMed ID | 20371366 | Mgi Jnum | J:160744 |
| Mgi Id | MGI:4455061 | Doi | 10.1016/j.febslet.2010.03.047 |
| Citation | Wang QH, et al. (2010) Opposite effects of Trichostatin A on activation of mast cells by different stimulants. FEBS Lett 584(11):2315-20 |
| abstractText | Mast cells (MCs) are activated upon stimulation via TLRs or FcepsilonRI, contributing to immune protection and/or leading to allergic diseases. In the present study, the effects of Trichostatin A (TSA) on the activation of MCs were analyzed with bone marrow-derived (BM) MCs. TSA increased the transcription and protein secretion of IL-6 in case of LPS-stimulation, in contrast to the suppressive effect on IgE-mediated activation of BMMCs. Chromatin immunoprecipitation assay showed IgE-mediated signaling-specific suppression of transcription factors recruitment to the IL-6 promoter. TSA-treatment inhibited nuclear translocation of NF-kappaB following IgE-mediated, but not LPS-induced activation in MCs. |
