| First Author | Yu HM | Year | 2010 |
| Journal | Dev Dyn | Volume | 239 |
| Issue | 7 | Pages | 2102-9 |
| PubMed ID | 20549736 | Mgi Jnum | J:161208 |
| Mgi Id | MGI:4457798 | Doi | 10.1002/dvdy.22336 |
| Citation | Yu HM, et al. (2010) Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis. Dev Dyn 239(7):2102-9 |
| abstractText | Wls/Evi/Srt encoding a multipass transmembrane protein has been identified as a regulator for proper sorting and secretion of Wnt in flies. We have previously demonstrated that Gpr177 is the mouse ortholog required for axis determination. Gpr177 is a transcriptional target of Wnt that is activated to assist its subcellular distribution in a feedback regulatory loop. We, therefore, proposed that reciprocal regulation of Wnt and Gpr177 is essential for the Wnt-dependent developmental and pathogenic processes. Here, we examine the expression pattern of Gpr177 in mouse development. Gpr177 is expressed in a variety of tissues and cell types during organogenesis. Furthermore, Gpr177 is a glycoprotein primarily accumulating in the Golgi apparatus in signal-producing cells. The glycosylation of Gpr177 is necessary for proper transportation in the secretory pathway. Our findings suggest that the Gpr177-mediated regulation of Wnt is crucial for organogenesis in health and disease. |
