| First Author | Chen YC | Year | 2010 |
| Journal | Behav Brain Res | Volume | 214 |
| Issue | 2 | Pages | 475-9 |
| PubMed ID | 20558209 | Mgi Jnum | J:162327 |
| Mgi Id | MGI:4818715 | Doi | 10.1016/j.bbr.2010.06.008 |
| Citation | Chen YC, et al. (2010) Behavioural phenotyping of dopamine transporter knockdown mice using local small interference RNA. Behav Brain Res 214(2):475-9 |
| abstractText | The objective of this study was to evaluate basic behavioural phenotypes and methamphetamine-induced hyperactivity in dopamine transporter (DAT) knockdown and control mice after local injections of small interference RNA into ventral tegmental area/substantia nigra once every other day for 14 days. Local knockdown of DAT expression in the mouse brain did not affect basic behavioural functions, but these mice displayed elevated depression-like immobility and a approximately 35% reduction of methamphetamine-induced hyperactivity. |
