| First Author | Rodriguez-Gil DJ | Year | 2010 |
| Journal | J Neurosci | Volume | 30 |
| Issue | 30 | Pages | 10067-75 |
| PubMed ID | 20668191 | Mgi Jnum | J:162854 |
| Mgi Id | MGI:4820445 | Doi | 10.1523/JNEUROSCI.1776-10.2010 |
| Citation | Rodriguez-Gil DJ, et al. (2010) Chromosomal location-dependent nonstochastic onset of odor receptor expression. J Neurosci 30(30):10067-75 |
| abstractText | As odorant receptors (ORs) are thought to be critical determinants of olfactory sensory neuron (OSN) axon targeting and organization, we examined the spatiotemporal onset of mice ORs expression from the differentiation of OSNs in the olfactory placode to an aging olfactory epithelium. ORs were first detected in the placode at embryonic day 9 (E9), at the onset of OSN differentiation but before axon extension. By E13, 22 of 23 ORs were expressed. Onset of individual OR expression was diverse; levels and patterns of expression were unique for each OR. Regional distribution of ORs within zones of the olfactory epithelium appeared stable across development; adult-like patterns were observed by E13. Finally, analysis of OR expression and chromosomal location suggests that ORs are not stochastically expressed; they show evidence of coordinated expression. Collectively, these studies demonstrate that ORs are not equally represented in the 'olfactome' across an animal's lifespan. |
