| First Author | Paiva KB | Year | 2010 |
| Journal | Acta Histochem | Volume | 112 |
| Issue | 5 | Pages | 508-17 |
| PubMed ID | 19608221 | Mgi Jnum | J:163300 |
| Mgi Id | MGI:4821548 | Doi | 10.1016/j.acthis.2009.05.007 |
| Citation | Paiva KB, et al. (2010) Differential Shh, Bmp and Wnt gene expressions during craniofacial development in mice. Acta Histochem 112(5):508-17 |
| abstractText | In this study, Bmp-4, Wnt-5a and Shh gene expressions were compared during early craniofacial development in mice by comparative non-isotopic in situ hybridization. Wild-type C57BL/6J mice were studied at various stages of embryonic development (from 8.5- to 13.5-day-old embryos--E8.5-13.5). During early odontogenesis, transcripts for Bmp-4, Shh and Wnt-5a were co-localised at the tooth initiation stage. At E8.5, Shh mRNA expression was restricted to diencephalon and pharyngeal endoderm. Before maxillae and mandible ossification, Bmp-4 and Wnt-5a signals were detected in the mesenchymal cells and around Meckel's cartilage. During palatogenesis, Shh was expressed only in the epithelium and Wnt-5a only in the mesenchyme of the elevating palatal shelves. During tongue development, Shh expression was found in mesenchyme, probably contributing to tongue miogenesis, while Wnt-5a signal was in the epithelium, possibly during placode development and papillae formation. Taken together, these findings suggest that Bmp-4, Shh and Wnt-5a gene expressions may act together on the epithelial-mesenchymal interactions occurring in several aspects of the early mouse craniofacial development, such as odontogenesis, neuronal development, maxillae and mandible ossification, palatogenesis and tongue formation. |
