| First Author | Polo SE | Year | 2010 |
| Journal | EMBO J | Volume | 29 |
| Issue | 18 | Pages | 3130-9 |
| PubMed ID | 20693977 | Mgi Jnum | J:164396 |
| Mgi Id | MGI:4833755 | Doi | 10.1038/emboj.2010.188 |
| Citation | Polo SE, et al. (2010) Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J 29(18):3130-9 |
| abstractText | The chromatin remodelling factor chromodomain helicase DNA-binding protein 4 (CHD4) is a catalytic subunit of the NuRD transcriptional repressor complex. Here, we reveal novel functions for CHD4 in the DNA-damage response (DDR) and cell-cycle control. We show that CHD4 mediates rapid poly(ADP-ribose)-dependent recruitment of the NuRD complex to DNA-damage sites, and we identify CHD4 as a phosphorylation target for the apical DDR kinase ataxia-telangiectasia mutated. Functionally, we show that CHD4 promotes repair of DNA double-strand breaks and cell survival after DNA damage. In addition, we show that CHD4 acts as an important regulator of the G1/S cell-cycle transition by controlling p53 deacetylation. These results provide new insights into how the chromatin remodelling complex NuRD contributes to maintaining genome stability. |
