| First Author | Lee BD | Year | 2010 |
| Journal | Nat Med | Volume | 16 |
| Issue | 9 | Pages | 998-1000 |
| PubMed ID | 20729864 | Mgi Jnum | J:164440 |
| Mgi Id | MGI:4833899 | Doi | 10.1038/nm.2199 |
| Citation | Lee BD, et al. (2010) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med 16(9):998-1000 |
| abstractText | Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease. |
