| First Author | Cha Y | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 19 | Pages | 4241-6 |
| PubMed ID | 20846526 | Mgi Jnum | J:164659 |
| Mgi Id | MGI:4834938 | Doi | 10.1016/j.febslet.2010.09.016 |
| Citation | Cha Y, et al. (2010) SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells. FEBS Lett 584(19):4241-6 |
| abstractText | Previous research indicated that ZAP70, a Syk family tyrosine kinase, is expressed in mouse embryonic stem cells (mESCs) and regulates the Janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) signaling through consolidating SHP1 enzymatic activity. In this study, we report that SHP2 is another downstream target of ZAP70 in mESCs. We found that SHP2 phosphorylation and enzymatic activity are affected by Zap70 expression. In addition, we present evidence that ERK pathways activated by ZAP70 and SHP2 reduce the protein level of leukemia inhibitory factor (LIF) receptor. Based on these results, we propose that SHP2 is an essential mediator of the ZAP70 signal to regulate JAK1/STAT3 and ERK pathways in undifferentiated mESCs. |
