| First Author | Oe S | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 15 | Pages | 3424-30 |
| PubMed ID | 20603120 | Mgi Jnum | J:165038 |
| Mgi Id | MGI:4836107 | Doi | 10.1016/j.febslet.2010.06.040 |
| Citation | Oe S, et al. (2010) Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons. FEBS Lett 584(15):3424-30 |
| abstractText | Several mRNAs are known to be targeted to dendrites in hippocampal neurons. In this study, we show that brain-derived neurotrophic factor (BDNF) mRNA has two distinct cis-acting dendritic targeting elements in the short 3' untranslated region (UTR): a constitutive element and an activity-dependent one. Moreover, deletion of serial cytoplasmic polyadenylation element (CPE)-like sequences in the short 3'UTR suppressed both constitutive and activity-dependent dendritic targeting. In addition to the interaction with cytoplasmic polyadenylation element binding protein-1 (CPEB-1), depolarization enhanced CPEB-1 recruitment to the activity-dependent targeting element. These results suggest that CPE-like sequences are involved in the activity-dependent as well as constitutive dendritic targeting of BDNF mRNA. |
