| First Author | Redford PS | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 8 | Pages | 2200-10 |
| PubMed ID | 20518032 | Mgi Jnum | J:165758 |
| Mgi Id | MGI:4838388 | Doi | 10.1002/eji.201040433 |
| Citation | Redford PS, et al. (2010) Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. Eur J Immunol 40(8):2200-10 |
| abstractText | IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence of IL-10 (IL-10(-/-) mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerated and enhanced IFN-gamma response in the lung, an increased influx of CD4(+) T cells into the lung, and enhanced production of chemokines and cytokines, including CXCL10 and IL-17, in both the lung and the serum. Neutralization of IL-17 affected neither the enhanced production of CXCL10 nor the accumulation of IFN-gamma-producing T cells in the lungs, but led to reduced numbers of granulocytes in the lung and reduced bacterial loads in the spleens of Mtb-infected mice. This suggests that IL-17 may contribute to dissemination of Mtb. |
