| First Author | Pham DN | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 22 | Pages | 4623-6 |
| PubMed ID | 20965183 | Mgi Jnum | J:167077 |
| Mgi Id | MGI:4867130 | Doi | 10.1016/j.febslet.2010.10.030 |
| Citation | Pham DN, et al. (2010) Reduced Ran expression in Ran(+/-) fibroblasts increases cytokine-stimulated nuclear abundance of the AP-1 subunits c-Fos and c-Jun. FEBS Lett 584(22):4623-6 |
| abstractText | Ran (Ras-related nuclear protein), a Ras family GTPase, is involved in multiple cellular functions, including the regulation of DNA replication, cell cycle progression, nuclear structure formation, RNA processing-exportation, and nuclear protein importation. Ran(+/-) embryonic stem (ES) cells were produced in an attempt to generate Ran null mutant mice. Even after an extremely large number of blastocyst injections, no Ran(+/-) chimeric mice could be generated. Ran(+/-) ES cell-derived fibroblasts showed reduced Ran protein expression, and manifested augmented nuclear abundance of AP-1 factors (c-Jun and c-Fos) upon cytokine stimulation. Our experiments demonstrated that intracellular Ran protein levels controlled the nuclear presence of certain transcription factors, such as c-Fos and c-Jun. |
