| First Author | Huff V | Year | 2011 |
| Journal | Nat Rev Cancer | Volume | 11 |
| Issue | 2 | Pages | 111-21 |
| PubMed ID | 21248786 | Mgi Jnum | J:168839 |
| Mgi Id | MGI:4939084 | Doi | 10.1038/nrc3002 |
| Citation | Huff V (2011) Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene. Nat Rev Cancer 11(2):111-21 |
| abstractText | Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding beta-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1? |
