| First Author | Chen Y | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 3 | Pages | 409-21 |
| PubMed ID | 21435588 | Mgi Jnum | J:169838 |
| Mgi Id | MGI:4943341 | Doi | 10.1016/j.immuni.2011.02.011 |
| Citation | Chen Y, et al. (2011) Foxp3(+) Regulatory T Cells Promote T Helper 17 Cell Development In Vivo through Regulation of Interleukin-2. Immunity 34(3):409-21 |
| abstractText | T helper 17 (Th17) cell development is driven by cytokines including transforming growth factor-beta (TGF-beta), interleukin-6 (IL-6), IL-1, and IL-23. Regulatory T (Treg) cells can provide the TGF-beta in vitro, but their role in vivo remains unclear, particularly because Treg cells inhibit inflammation in many models of Th17 cell-associated autoimmunity. We used mice expressing Diphtheria toxin receptor under control of the Foxp3 promoter to deplete Foxp3(+) Treg cells in adult mice during in vivo Th17 cell priming. Treg cell depletion resulted in a reduced frequency of antigen-specific IL-17 producers in draining lymph nodes and blood, correlating with reduced inflammatory skin responses. In contrast, Treg cells did not promote IL-17 secretion after initial activation stages. Treg cell production of TGF-beta was not required for Th17 cell promotion, and neither was suppression of Th1 cell-associated cytokines. Rather, regulation of IL-2 availability and resultant signaling through CD25 by Treg cells was found to play an important role. |
