| First Author | Mallevaey T | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 3 | Pages | 315-26 |
| PubMed ID | 21376640 | Mgi Jnum | J:170326 |
| Mgi Id | MGI:4946325 | Doi | 10.1016/j.immuni.2011.01.013 |
| Citation | Mallevaey T, et al. (2011) A Molecular Basis for NKT Cell Recognition of CD1d-Self-Antigen. Immunity 34(3):315-26 |
| abstractText | The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have characterized NKT TCR recognition of CD1d molecules loaded with natural self-antigens (Ags) and report the 2.3 A resolution structure of an autoreactive NKT TCR-phosphatidylinositol-CD1d complex. NKT TCR recognition of self- and foreign antigens was underpinned by a similar mode of germline-encoded recognition of CD1d. However, NKT TCR autoreactivity is mediated by unique sequences within the non-germline-encoded CDR3beta loop encoding for a hydrophobic motif that promotes self-association with CD1d. Accordingly, NKT cell autoreactivity may arise from the inherent affinity of the interaction between CD1d and the NKT TCR, resulting in the recognition of a broad range of CD1d-restricted self-antigens. This demonstrates that multiple self-antigens can be recognized in a similar manner by autoreactive NKT TCRs. |
