| First Author | D'Amours G | Year | 2011 |
| Journal | Behav Brain Res | Volume | 221 |
| Issue | 1 | Pages | 108-17 |
| PubMed ID | 21376085 | Mgi Jnum | J:171728 |
| Mgi Id | MGI:4950834 | Doi | 10.1016/j.bbr.2011.02.030 |
| Citation | D'Amours G, et al. (2011) Differential gene expression profiling in the mouse brain during motor skill learning: Focus on the striatum structure. Behav Brain Res 221(1):108-17 |
| abstractText | Much research has implicated the striatum in motor learning, but the underlying mechanism is still under extensive investigation. In this study, genome-wide analysis of gene expression was conducted in mice that have learned a complex motor task. It is well recognized that successful learning requires repetitive training and is learned slowly over several training sessions. We therefore used mice that have fully learned the accelerating rotarod task that discriminates the faster and slower phases of motor learning. As important modulators of movement behavior, the striatum was the target of this analysis along with the cerebellum and anterior cortex. To identify potential genes implicated in long memorization process, we compared the lists of genes modulated in the striatum to those modulated in the cerebellum and cortex. As a second approach, we also determined which gene ontology categories were enriched in modulated striatal genes and identified genes with the highest numbers of annotation throughout categories. Although only some of these changes were further confirmed by RT-PCR, these two complementary analyses allowed the identification of highly relevant genes like calcium/calmodulin-dependent protein kinase 2, protein kinase C zeta and N-methyl-d-aspartate receptors. Notably, these genes are all associated with synaptic plasticity, suggesting that stabilized neuronal connections in the striatum are the foundation of durable motor memory. Our study provides the first report of a whole genome analysis of gene expression in mice that have memorized a new complex motor task, and expands our knowledge on striatal gene expression changes associated with motor skill learning. |
