| First Author | Porta-de-la-Riva M | Year | 2011 |
| Journal | Biochem J | Volume | 435 |
| Issue | 3 | Pages | 563-8 |
| PubMed ID | 21361876 | Mgi Jnum | J:171731 |
| Mgi Id | MGI:4950837 | Doi | 10.1042/BJ20102057 |
| Citation | Porta-de-la-Riva M, et al. (2011) TFCP2c/LSF/LBP-1c is required for Snail1-induced fibronectin gene expression. Biochem J 435(3):563-8 |
| abstractText | Fibronectins are cell-secreted glycoproteins that modulate cell attachment, spreading, migration, morphology, differentiation and oncogenic transformation. Fibronectin expression is activated during EMT (epithelial-mesenchymal transition) and is a hallmark of mesenchymal cells. It is shown in the present study that a transcription factor previously unrelated with EMT, TFCP2c/LSF/LBP-1c, was translocated to the nucleus and bound to the fibronectin promoter upon EMT induction by Snail1. Consequently, the interference of TFCP2c/LSF/LBP-1c's activity prevented fibronectin expression. Moreover, TFCP2c/LSF/LBP-1c was detected in nuclei of embryonic dermal mesenchymal cells adjacent to the hair bud, a cell population that expresses endogenous nuclear Snail1 and fibronectin. Therefore we indicate a new molecular role for TFCP2c/LSF/LBP-1c in fibronectin expression. |
