| First Author | Penna E | Year | 2011 |
| Journal | EMBO J | Volume | 30 |
| Issue | 10 | Pages | 1990-2007 |
| PubMed ID | 21468029 | Mgi Jnum | J:171977 |
| Mgi Id | MGI:5002732 | Doi | 10.1038/emboj.2011.102 |
| Citation | Penna E, et al. (2011) microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J 30(10):1990-2007 |
| abstractText | Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases. |
