| First Author | Zhang Y | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 9 | Pages | 1269-75 |
| PubMed ID | 21459093 | Mgi Jnum | J:171980 |
| Mgi Id | MGI:5002735 | Doi | 10.1016/j.febslet.2011.03.059 |
| Citation | Zhang Y, et al. (2011) Nuclear receptor SHP inhibition of Dnmt1 expression via ERRgamma. FEBS Lett 585(9):1269-75 |
| abstractText | We describe a transcriptional mechanism regulating the expression of Dnmt1 by nuclear receptors. We show that ERRgamma functions as a transcriptional activator of mouse and human Dnmt1 expression by direct binding to its response elements (ERE1/ERE2) in the dnmt1/DNMT1 promoters. The induction of Dnmt1 by ERRgamma is repressed by SHP through SHP inhibition of ERRgamma transactivity, diminishing ERRgamma recruitment to the Dnmt1 promoter, and altering the conformation of local chromatin from an active mode by ERRgamma to an inactive mode. Our study provides the first evidence for nuclear receptor mediated regulation of Dnmt1 expression through ERRgamma and SHP crosstalk. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: ERR gammaphysically interacts with SHP by anti tag coimmunoprecipitation (View interaction). |
