| First Author | Ikeda K | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 9 | Pages | 1303-9 |
| PubMed ID | 21439958 | Mgi Jnum | J:171992 |
| Mgi Id | MGI:5002747 | Doi | 10.1016/j.febslet.2011.03.038 |
| Citation | Ikeda K, et al. (2011) Conditional expression of constitutively active estrogen receptor alpha in osteoblasts increases bone mineral density in mice. FEBS Lett 585(9):1303-9 |
| abstractText | Estrogen plays an important role in maintaining bone density in women. Estrogen receptor (ER) is expressed in osteoblasts and osteoclasts; however, the precise mechanism of ER in bone is not fully understood. In the present study, we generated a conditional transgenic mouse caERalpha(ColI) that expresses the constitutively active ERalpha in osteoblasts using collagen type I promoter-driven Cre transgenic mice. The caERalpha(ColI) mice showed increased bone mineral density (BMD). Osteoblasts prepared from caERalpha(ColI) mice expressed high levels of osteoprotegerin and decreased levels of IL-6, both of which are known to regulate osteoclast differentiation. These results suggest that ERalpha regulates osteoprotegerin and IL-6 production in osteoblasts and modulates BMD. The conditional transgenic mouse model is useful for understanding the in vivo function of ERalpha. |
