| First Author | Stahl N | Year | 1994 |
| Journal | Science | Volume | 263 |
| Issue | 5143 | Pages | 92-5 |
| PubMed ID | 8272873 | Mgi Jnum | J:172926 |
| Mgi Id | MGI:5009217 | Doi | 10.1126/science.8272873 |
| Citation | Stahl N, et al. (1994) Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science 263(5143):92-5 |
| abstractText | A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines. |
