| First Author | Hashimoto Y | Year | 2011 |
| Journal | J Pathol | Volume | 224 |
| Issue | 3 | Pages | 289-300 |
| PubMed ID | 21618240 | Mgi Jnum | J:173323 |
| Mgi Id | MGI:5013864 | Doi | 10.1002/path.2894 |
| Citation | Hashimoto Y, et al. (2011) The roles of fascins in health and disease. J Pathol 224(3):289-300 |
| abstractText | Fascins are actin-binding proteins that cross-link filamentous actin into tightly packed parallel bundles. These bundles are important for the organization and morphology of an extremely diverse set of sub-cellular structures that include dynamic and stable cell-surface protrusions, stress fibres, and the specialized actin bundles of photoreceptor and stereocilia cells. In this review, we discuss the fascin gene family and its evolution, the actin-bundling activity of fascins and the molecular pathways by which it is regulated, and the role of the diverse actin/fascin structures in normal cellular processes. We discuss the mechanisms by which fascins contribute to disease pathologies, especially cancer, where fascin-1 is emerging as a novel therapeutic target in carcinoma metastasis. Copyright (c) 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
