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Publication : Turning reciprocal feedback regulation into combination therapy.

First Author  Thompson TC Year  2011
Journal  Cancer Cell Volume  19
Issue  6 Pages  697-9
PubMed ID  21665144 Mgi Jnum  J:173564
Mgi Id  MGI:5014456 Doi  10.1016/j.ccr.2011.05.022
Citation  Thompson TC (2011) Turning reciprocal feedback regulation into combination therapy. Cancer Cell 19(6):697-9
abstractText  Two recent Cancer Cell articles report the discovery of reciprocal feedback regulation between androgenic and PTEN loss/PI3K-AKT signaling in prostate cancer. Both studies link endocrine regulation with a common oncogenic pathway, which led to the development of a combination therapeutic approach with immediate application in prostate cancer.
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