| First Author | Chen W | Year | 2011 |
| Journal | Birth Defects Res B Dev Reprod Toxicol | Volume | 92 |
| Issue | 2 | Pages | 97-101 |
| PubMed ID | 21328691 | Mgi Jnum | J:173587 |
| Mgi Id | MGI:5014479 | Doi | 10.1002/bdrb.20278 |
| Citation | Chen W, et al. (2011) Effects of chlorpyrifos exposure on kidney Notch2-Jagged1 pathway of early prenatal embryo. Birth Defects Res B Dev Reprod Toxicol 92(2):97-101 |
| abstractText | AIMS: To evaluate the effects of this insecticide on the embryonic development of kidney and to assess the important role of Notch2-Jagged1 pathway in this duration. METHODS AND RESULTS: Chlorpyrifos (CPF) 5 mg/kg/d were administrated on gestation 7.5-11.5 day by subcutaneous injection. On gestation 16.5 day, the normal embryo kidney developed through S shape duration to the original kidney, which had the nephrons and could start to secret the urine. But for the CPF-treated mice, the embryo kidney developed much more slowly, they did not show the S shape and the nephrons. The Notch2-Jagged1 pathway should be expressed stronger in the normal embryo kidney on gestation 16.5 day, but for the CPF-treated mice we found the obvious weak pathway staining. CONCLUSIONS: CPF broke the Notch2-Jagged1 pathway during the embryo kidney development, and the Notch2-Jagged1 pathway plays an important role in the S shape to original kidney formation duration. |
