| First Author | Munkley J | Year | 2011 |
| Journal | Nucleic Acids Res | Volume | 39 |
| Issue | 7 | Pages | 2671-7 |
| PubMed ID | 21109536 | Mgi Jnum | J:173803 |
| Mgi Id | MGI:5050377 | Doi | 10.1093/nar/gkq1190 |
| Citation | Munkley J, et al. (2011) Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. Nucleic Acids Res 39(7):2671-7 |
| abstractText | Cyclin E supports pre-replication complex (pre-RC) assembly, while cyclin A-associated kinase activates DNA synthesis. We show that cyclin E, but not A, is mounted upon the nuclear matrix in sub-nuclear foci in differentiated vertebrate cells, but not in undifferentiated cells or cancer cells. In murine embryonic stem cells, Xenopus embryos and human urothelial cells, cyclin E is recruited to the nuclear matrix as cells differentiate and this can be manipulated in vitro. This suggests that pre-RC assembly becomes spatially restricted as template usage is defined. Furthermore, failure to become restricted may contribute to the plasticity of cancer cells. |
