| First Author | Vesterlund L | Year | 2011 |
| Journal | Int J Dev Biol | Volume | 55 |
| Issue | 3 | Pages | 313-9 |
| PubMed ID | 21710437 | Mgi Jnum | J:174064 |
| Mgi Id | MGI:5051850 | Doi | 10.1387/ijdb.103240lv |
| Citation | Vesterlund L, et al. (2011) Co-localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo development. Int J Dev Biol 55(3):313-9 |
| abstractText | During development there is a multitude of signaling events governing the assembly of the developing organism. Receptors for signaling molecules such as fibroblast growth factor receptor 2 (FGFR2) enable the embryo to communicate with the surrounding environment and activate downstream pathways. The neural cell adhesion molecule (NCAM) was first characterized as a cell adhesion molecule highly expressed in the nervous system, but recent studies have shown that it is also a signaling receptor. Using a novel single oocyte adaptation of the proximity ligation assay, we here show a close association between NCAM and FGFR2 in mouse oocytes and 2-cell embryos. Real-time PCR analyses revealed the presence of messenger RNA encoding key proteins in downstream signaling pathways in oocytes and early mouse embryos. In summary these findings show a co-localization of NCAM and FGFR2 in early vertebrate development with intracellular signaling pathways present to enable a cellular response. |
