| First Author | Shen SM | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 14 | Pages | 2307-12 |
| PubMed ID | 21664907 | Mgi Jnum | J:174219 |
| Mgi Id | MGI:5052215 | Doi | 10.1016/j.febslet.2011.05.061 |
| Citation | Shen SM, et al. (2011) Apoptosis-inducing factor is a target gene of C/EBPalpha and participates in adipocyte differentiation. FEBS Lett 585(14):2307-12 |
| abstractText | Besides the contribution in cell death, apoptosis-inducing factor (AIF) also exerts roles in other cellular activities, which are largely unknown. The CCAAT-enhancer binding protein alpha (C/EBPalpha) is required for differentiation of adipocytes and granulocytes. Here we report that, during 3T3-L1 adipocyte differentiation, AIF expression is robustly upregulated via transcriptional regulation by C/EBPalpha. The upregulated effect is also confirmed by knockdown and ectopic expression of C/EBPalpha in U937 and MCF-7 cells respectively with and without endogenous expression of C/EBPalpha protein. We also reveal that AIF knockdown attenuates 3T3-L1 adipocyte differentiation, presumably due to the mitochondrial respiratory chain deficiency. These results provide evidence for the role of AIF in adipocyte differentiation. |
