| First Author | Kim JY | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 14 | Pages | 2144-50 |
| PubMed ID | 21627969 | Mgi Jnum | J:174229 |
| Mgi Id | MGI:5052225 | Doi | 10.1016/j.febslet.2011.05.034 |
| Citation | Kim JY, et al. (2011) TRADD is critical for resistance to TRAIL-induced cell death through NF-kappaB activation. FEBS Lett 585(14):2144-50 |
| abstractText | One major obstacle in the clinical application of TRAIL as a cancer therapeutic agent is the acquisition of TRAIL resistance. We found that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis. Enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB activation, indicating that the pro-survival function of TRADD in TRAIL signaling is mediated at least in part via NF-kappaB activation. Moreover, siRNA knock-down of TRADD in cancer cells sensitizes them to TRAIL-induced apoptosis. Thus, TRADD has a survival role in TRAIL signaling and may be one potential target for overcoming TRAIL resistance in cancer therapy. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: TRAILphysically interacts with FADD and RIP1 by pull down(View interaction). |
