| First Author | Hayn-Leichsenring G | Year | 2011 |
| Journal | Neuroscience | Volume | 189 |
| Pages | 68-78 | PubMed ID | 21651965 |
| Mgi Jnum | J:175654 | Mgi Id | MGI:5286809 |
| Doi | 10.1016/j.neuroscience.2011.05.038 | Citation | Hayn-Leichsenring G, et al. (2011) Cellular distribution of metastasis suppressor 1 and the shape of cell bodies are temporarily altered in Engrailed-2 overexpressing cerebellar Purkinje cells. Neuroscience 189:68-78 |
| abstractText | Metastasis suppressor 1 (MTSS1, BEG4, MIM) is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. However, only little is known about its expression in the central nervous system (CNS), and functions within the CNS have not been addressed so far. Here, we show that MTSS1 was expressed in postmitotic neurons of the cerebellar cortex. Within Purkinje cells, higher amounts of MTSS1 were temporarily localized in the axonal somatic compartment than in the dendritic compartment. In L7En-2 transgenic mice, in which the segment-polarity gene and regulator of neuronal maturation Engrailed-2 is overexpressed specifically in cerebellar Purkinje cells, MTSS1 was homogenously distributed within Purkinje cell somata throughout development. In parallel to the altered distribution of MTSS1 in L7En-2 Purkinje cells, L7En-2 Purkinje cell somata were distorted and in some cells invaginations of the plasma membrane were observed. These invaginations were only found in L7En-2 neurons, and displayed multiple synapses which could not be seen at the smooth surface of wildtype Purkinje cell somata. Current knowledge about MTSS1 function in vitro and the correlation between MTSS1 localization and the occurrence of membrane alterations in L7En-2 Purkinje cells described here suggest that MTSS1 might be involved in shaping neuronal membranes in vivo. |
